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Comparative Study
. 2000 Oct;2(10):703-8.
doi: 10.1038/35036326.

New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals

S Hinuma  1 , Y Shintani, S Fukusumi, N Iijima, Y Matsumoto, M Hosoya, R Fujii, T Watanabe, K Kikuchi, Y Terao, T Yano, T Yamamoto, Y Kawamata, Y Habata, M Asada, C Kitada, T Kurokawa, H Onda, O Nishimura, M Tanaka, Y Ibata, M Fujino
Affiliations
Comparative Study

New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals

S Hinuma et al. Nat Cell Biol. 2000 Oct.

Abstract

Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, OT7T022, specifically respond to synthetic hRFRP-1 and hRFRP-3 but not to hRFRP-2. RFRP and OT7T022 mRNAs are expressed in particular regions of the rat hypothalamus, and intracerebroventricular administration of hRFRP-1 increases prolactin secretion in rats. Our results indicate that a variety of RFamide-related peptides may exist and function in mammals.

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