Failure to protect Mus musculus against Plasmodium berghei with footpad injections of killed parasites incorporated in complete Freund's adjuvant
- PMID: 1102649
Failure to protect Mus musculus against Plasmodium berghei with footpad injections of killed parasites incorporated in complete Freund's adjuvant
Abstract
The stimulation of cell-mediated immunity by the injection of antigen from killed parasites incorporated in complete Freund's adjuvant did not protect Mus musculus from the erythrocytic stages of Plasmodium berghei. Agglutinating antibodies could not be detected, but delayed hypersensitivity was demonstrable. Apparently thymocyte sensitization alone was not sufficient to afford protection.
Similar articles
-
[Construction and expression of Plasmodium berghei chimeric protein in Pichia pastoris and its immunogenicity in mice].Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2008 Oct 30;26(5):327-31. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2008. PMID: 19157293 Chinese.
-
Role of macrophages in experimental malaria: VI--Effect of Freund's complete adjuvant in Plasmodium berghei infected mice.J Commun Dis. 1999 Jun;31(2):121-6. J Commun Dis. 1999. PMID: 10810600
-
On the development of delayed skin hypersensitivity following separate injection of antigen and Freund's complete adjuvant. Preliminary report.Jpn J Tuberc Chest Dis. 1970 Jul;16(1):44-51. Jpn J Tuberc Chest Dis. 1970. PMID: 5312217 No abstract available.
-
Effect of previous injection of antigen on the development of delayed skin hypersensitivity following injection of the same antigen in Freund's complete adjuvant. With special reference to the site and time interval of the two injections.Jpn J Tuberc Chest Dis. 1970 Jul;16(1):52-6. Jpn J Tuberc Chest Dis. 1970. PMID: 5312218 No abstract available.
-
A differentiated approach to testing skin sensitization. Proposal for a new test guideline skin sensitization.Arch Toxicol. 1989;63(2):81-4. doi: 10.1007/BF00316428. Arch Toxicol. 1989. PMID: 2658921 Review.
Cited by
-
A perspective on malaria vaccines.Bull World Health Organ. 1980;58(6):897-908. Bull World Health Organ. 1980. PMID: 6783333 Free PMC article.
-
Protection of mice against malaria by a killed vaccine: differences in effectiveness against P. yoelii and P. berghei.Immunology. 1977 Oct;33(4):507-15. Immunology. 1977. PMID: 336522 Free PMC article.
-
Glucan-enhanced immunogenicity of killed erythrocyte stages of Plasmodium berghei.Infect Immun. 1981 May;32(2):542-6. doi: 10.1128/iai.32.2.542-546.1981. Infect Immun. 1981. PMID: 7019074 Free PMC article.
-
Effect of selenium and dimethyl dioctadecyl ammonium bromide on the vaccine-induced immunity of Swiss-Webster mice against malaria (Plasmodium berghei).Infect Immun. 1980 Jan;27(1):87-9. doi: 10.1128/iai.27.1.87-89.1980. Infect Immun. 1980. PMID: 6987181 Free PMC article.