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. 2000 Oct 10;97(21):11135-6.
doi: 10.1073/pnas.97.21.11135.

Sticking together

M B Kennedy  1
Affiliations

Sticking together

M B Kennedy. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Gephyrin (93 kDa) binds glycine receptors and tubulin in vitro and is required for clustering of glycine and GABAA receptors at synapses; yet it does not associate with GABAA receptors in vitro. GABARAP (14 kDa) binds a subunit of the GABAA receptor, gephyrin, and tubulin in vitro. Furthermore, GABARAP recruits GABAA receptors into clusters at the plasma membrane in heterologous quail fibroblast cells. However, GABARAP does not colocalize with gephyrin or GABAA receptors in primary neurons. Instead it is associated with intracellular vesicles. The data suggest that GABARAP may mediate transport or targeting of gephyrin and GABAA receptors, but another unknown protein may link gephyrin and the GABAA receptor at synapses. Chen et al. (12) also show that clustered receptors recruited to the membrane by GABARAP in quail cells have a 4-fold reduced affinity for GABA. If the GABARAP promoted clustering resembles that at synapses, the implication is that clustering of GABAA receptors and association with the subcellular cytoskeleton can dramatically alter their kinetic properties.
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References

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