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Clinical Trial
. 2000 Nov;83(9):1124-7.
doi: 10.1054/bjoc.2000.1425.

A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy

J A Kohler  1 , J Imeson, C Ellershaw, S O Lie
Affiliations
Free PMC article
Clinical Trial

A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy

J A Kohler et al. Br J Cancer. 2000 Nov.
Free PMC article

Abstract

One hundred and seventy-five children with Stage 3 or 4 neuroblastoma who had obtained a good response to conventional therapy were randomly allocated to 13-Cis retinoic acid at a dose of 0.75 mg/kg/day or placebo for up to 4 years. Toxicity was mild but no advantage in event-free survival was shown for the children receiving retinoic acid.

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