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Clinical Trial
. 1975 Sep 6;2(10):392-3.
doi: 10.5694/j.1326-5377.1975.tb105901.x.

A controlled trial of maprotiline (Ludiomil) in depressed outpatients

P McCallum, R Meares
Clinical Trial

A controlled trial of maprotiline (Ludiomil) in depressed outpatients

P McCallum et al. Med J Aust. .

Abstract

A double blind comparison is reported of a new tetracyclic antidepressant, maprotiline, with amitriptyline and placebo in psychiatric outpatients. Amitriptyline was significantly more effective than placebo in its global effect on depression. Maprotiline emerged as neither inferior to amitriptyline nor superior to placebo. Methodological difficulties prevented an adequate assessment of the anxiolytic activity of maprotiline.

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