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. 1975;137(2):89-99.
doi: 10.1007/BF00341675.

Lomofungin inhibition of allophanate hydrolase synthesis in Saccharomyces cerevisiae

R P Lawther, S L Phillips, T G Cooper

Lomofungin inhibition of allophanate hydrolase synthesis in Saccharomyces cerevisiae

R P Lawther et al. Mol Gen Genet. 1975.

Abstract

The RNA polymerase inhibitor, lomofungin has been used to determine the half life of specific synthetic capacities (invertase and alpha-glucosidase) as well as that for gross protein synthesis. In both cases the studies conclude that cognate messenger RNAs decay with a half life of approximately 20 minutes. This antibiotic has been used to determine the half life of allophanate hydrolase specific synthetic capacity. We find that it decays with a half life of about three minutes; a value that agrees with the decay rates of allophanate hydrolase synthetic capacity following removal of inducer. These observations argue that mRNA may be metabolized by two separate routes in Saccharomyces.

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References

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