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. 1975 Nov 7;190(4214):571-2.

Transmission of Creutzfeldt-Jakob disease from man to the guinea pig

E E Manuelidis
  • PMID: 1103289

Transmission of Creutzfeldt-Jakob disease from man to the guinea pig

E E Manuelidis. Science. .

Abstract

Intracerebral and intraperitoneal inoculation of two guinea pigs with biopsy material from a patient with Creutzfeldt-Jakob disease produced a similar fatal encephalopathy characterized by status spongiosus 422 and 512 days after inoculation. Serial transmission of this disease from guinea pig to guinea pig was achieved in subsequent passages.

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