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. 2000;2000(4):CD002762.
doi: 10.1002/14651858.CD002762.

Single dose piroxicam for acute postoperative pain

J E Edwards  1 , Y K Loke, R A Moore, H J McQuay
Affiliations

Single dose piroxicam for acute postoperative pain

J E Edwards et al. Cochrane Database Syst Rev. 2000.

Abstract

Background: Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) with analgesic properties, and is used mainly for treating rheumatic disorders. Some drugs have been directly compared against each other within a trial setting to determine their relative efficacies, whereas other have not. It is possible, however, to compare analgesics indirectly by examining the effectiveness of each drug against placebo when used in similar clinical situations.

Objectives: To determine the analgesic efficacy and adverse effects of single-dose piroxicam compared with placebo in moderate to severe postoperative pain. To compare the effects of piroxicam with other analgesics.

Search strategy: Published reports were identified from systematic searching of Medline, Biological Abstracts, Embase, The Cochrane Library and the Oxford Pain Relief Database. Additional studies were identified from the reference lists of retrieved reports.

Selection criteria: The following inclusion criteria were used: full journal publication, randomised placebo controlled trial, double-blind design, adult patients, postoperative pain of moderate to severe intensity at the baseline assessment, postoperative administration of oral or intramuscular piroxicam.

Data collection and analysis: Summed pain intensity and pain relief data were extracted and converted into dichotomous information to yield the number of patients obtaining at least 50% pain relief. This was used to calculate estimates of relative benefit and number-needed-to-treat for one patient to obtain at least 50% pain relief. Information was collected on adverse effects and estimates of relative risk and number-needed-to-harm were calculated.

Main results: Three trials (141 patients) compared oral piroxicam 20 mg with placebo and one (15 patients) compared oral piroxicam 40 mg with placebo. For single doses of piroxicam 20 mg and 40 mg the respective numbers-needed-to-treat for at least 50% pain relief were 2.7 (2.1 to 3.8) [95% confidence interval] and 1.9 (1.2 to 4.3) [95% confidence interval] compared with placebo over 4-6 hours in moderate to severe postoperative pain. The reported incidence of adverse effects was no higher with piroxicam (20 mg or 40 mg) than with placebo.

Reviewer's conclusions: Piroxicam appears to be of similar efficacy to other non-steroidal anti-inflammatory drugs (NSAIDs) and intramuscular morphine 10 mg when used as a single oral dose in the treatment of moderate to severe postoperative pain.

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Conflict of interest statement

YKL and SD have no interests to declare. RAM has been a consultant for MSD. RAM and HJM have consulted for various pharmaceutical companies. RAM, HJM and JR have received lecture fees from pharmaceutical companies related to analgesics and other healthcare interventions. All authors have received research support from charities, government and industry sources at various times: no such support was received for this work.

Figures

1.1
1.1. Analysis
Comparison 1 Piroxicam 20 mg versus placebo, Outcome 1 Participants with at least 50% pain relief.
2.1
2.1. Analysis
Comparison 2 Piroxicam 40 mg versus placebo, Outcome 1 Participants with at least 50% pain relief.
See this image and copyright information in PMC

References

References to studies included in this review

Dolci 1994 {published data only}
    1. Dolci G, Ripari M, Pacifici L, Umile A. Evaluation of piroxicam‐beta‐cyclodextrin, piroxicam, paracetamol and placebo in postoperative oral surgery pain. International Journal of Clinical Pharmacology Research 1994;14:185‐91. - PubMed
Sunshine 1988a {published data only}
    1. Sunshine A, Roure C, Colon A, Olson, NZ, Gonzalez L, Siegel C, et al. Analgesic efficacy of piroxicam in the treatment of postoperative pain. The American Journal of Medicine 1988;84(5A):16‐22. - PubMed
Sunshine 1988b {published data only}
    1. Sunshine A, Roure C, Colon A, Olson, NZ, Gonzalez L, Siegel C, et al. Analgesic efficacy of piroxicam in the treatment of postoperative pain. The American Journal of Medicine 1988;84(5A):16‐22. - PubMed

References to studies excluded from this review

Alpaslan 1997 {published data only}
    1. Alpaslan C, Alpaslan G, Ugar D. Postoperative pain control by single doses of piroxicam administered sublingually and aspirin. Journal of Marmara University Dental Faculty 1997;2(4):658‐64. - PubMed
Anderson 1993 {published data only}
    1. Anderson P, Lysak SZ, Carithers RA, DeVane G, Smith ML, Bates GW. Efficacy of fentanyl, ketorolac and piroxicam for postoperative analgesia. Journal of the American Association of Nurse Anesthetists 1993;61(4):427‐8.
Anonymous 1995 {published data only}
    1. Anonymous. Heeft Brexine(r) voordelen boven andere pijnstillers. Geneesmiddelenbulletin 1995;29(3):30‐1.
Arvidsson 1987 {published data only}
    1. Arvidsson I, Eriksson E. A double blind trial of NSAID double blind trial of NSAID versus placebo during rehabilitation. Orthopedics 1987;10(7):1007‐14. - PubMed
Barbieri 1982 {published data only}
    1. Barbieri E, Pannone G, Arosio A, Santilli A. A comparison in the orthopedic‐traumatologic field between the analgesic effect of piroxicam and ibuprofen, two non‐steroidal anti‐inflammatory drugs (NSAIDS). Terapie Essenziali in Clinica 1982;2:283‐7.
Bauduin 1995 {published data only}
    1. Bauduin H, Famaey JP. Comparison of the analgesic effects of beta‐cyclodextrin‐piroxicam, sodium naproxen and potassium diclofenac utilizing the dental pain model. Journal of Pharmaceutical Care in Pain and Symptom Control 1995;3(2):19‐29.
Bigler 1992 {published data only}
    1. Bigler D, Moller J, Kamp Jensen M, Berthelsen P, Hjortso NC, Kehlet H. Effect of piroxicam in addition to continuous thoracic epidural bupivacaine and morphine on postoperative pain and lung function after thoracotomy. Acta Anaesthesiologica Scandinavica 1992;36(7):647‐50. - PubMed
Boeckstyns 1992 {published data only}
    1. Boeckstyns MEH, Backer M, Petersen EM, Hoj I, Albrechtsen H, Andersen HB. Piroxicam spares buprenorphine after total joint replacement. Controlled study of pain treatment in 81 patients. Acta Orthopaedica Scandinavica 1992;63(6):658‐60. - PubMed
Breivik 1984 {published data only}
    1. Breivik H, Stenseth R, Apalseth K, Spilsberg AM. Piroxicam, acetylsalicylic acid and placebo for postoperative pain. Acta Anaesthesiologica Scandinavica 1984;28(1):37‐9. - PubMed
Bruno 1987 {published data only}
    1. Bruno E. Not available [Il dolore post‐estravattivo. Trattamento analgesico con piroxicam]. Dental Cadmos 1987;55:14. - PubMed
Celenza 1995 {published data only}
    1. Celenza M, Pillone P, Longeri A, Cremonesi G. Piroxicam‐beta‐cyclodextrin vs ketorolac‐tromethamine in the treatment of post‐surgical pain. Gazzetta Medica Italiana Archivio Per Le Scienze Mediche 1995;154(2):81‐5.
Cruz 1984 {published data only}
    1. Cruz R. An oral analgesic study of piroxicam (feldene) in post‐operative dental pain. Current Therapeutic Research 1984;36:1256‐60.
DeAndrade 1994 {published data only}
    1. DeAndrade JR, Maslanka M, Maneatis T, Bynum L, Burchmore M. The use of ketorolac in the management of postoperative pain. Orthopedics 1994;17(2):157‐66. - PubMed
Desjardins 1988 {published data only}
    1. Desjardins PJ. Analgesic efficacy of piroxicam in postoperative dental pain. The American Journal of Medicine 1988;84(5A):35‐41. - PubMed
Desjardins 1990 {published data only}
    1. Desjardins PJ, Iranpour B, Handelman S, Emmings F. Piroxicam in dental pain. Clinical Pharmacology and Therapeutics 1990;47(2):163.
Dolci 1993 {published data only}
    1. Dolci G, Ripari M, Pacifici L, Umile A. [Analgesic efficacy and the tolerance for piroxicam‐beta‐cyclodextrin compared to piroxicam, paracetamol and placebo in the treatment of postextraction dental pain]. Minerva Stomatologica 1993;42(5):235‐41. - PubMed
Fasting 1992 {published data only}
    1. Fasting OJ, Uppheim G, Thoresen BO. [Piroxicam in arthroscopic surgery of the knee. A prospective randomised double‐blind multicenter study with preoperative and short term postoperative treatment]. Tidsskrift for Den Norske Laegeforening 1992;112(9):1161‐4. - PubMed
Frezza 1985 {published data only}
    1. Frezza R, Bolognesi P, Bernardi F. Comparison of the action of 3 non‐steroidal anti‐inflammatory agents in the control of post‐operative pain. Effectiveness of NSAID against pain. Attualita Dentale 1985;1:40‐2. - PubMed
Hilvano 1984 {published data only}
    1. Hilvano S. A non‐comparative study of the analgesic activity of piroxicam (feldene) in patients with post‐operative pain following minor surgery. Current Therapeutic Research 1984;36:1269‐76.
Hutchison 1990 {published data only}
    1. Hutchison GL, Crofts SL, Gray IG. Preoperative piroxicam for postoperative analgesia in dental surgery. British Journal of Anaesthesia 1990;65(4):500‐3. - PubMed
Jain 1978 {published data only}
    1. Jain AK, McMahon FG, Ryan JR, Raphan H, Richard W. Piroxicam, a novel analgesic in postpartum pain. European Journal of Rheumatology and Inflammation 1978;1:356‐9.
Jonsson 1990 {published data only}
    1. Jonsson T, Rude C, Randberg FA, Johansen T, Lang‐Jenson T, Jensen NH. Postoperative pain treated with piroxicam and buprenorphine, each drug alone or in a combination. Pain 1990;41(Supplement 1):S138.
Kakutani 1983 {published data only}
    1. Kakutani K. [BAXO (piroxicam) for minor postsurgical pain in the oral area]. Shikai Tenbo = Dental outlook 1983;62(1):205‐10. - PubMed
Kavanagh 1994 {published data only}
    1. Kavanagh BP, Katz J, Sandler AN. Pain control after thoracic surgery: A review of current techniques. Anesthesiology 1994;81(3):737‐59. - PubMed
Laska 1987 {published data only}
    1. Laska E, Sunshine A, Colon A, Olson N, Siegel C. Piroxicam, aspirin and placebo in postoperative pain. Pain 1987;30(Supplement 1):S55.
Lysak 1994 {published data only}
    1. Lysak SZ, Anderson PT, Carithers RA, DeVane GG, Smith ML, Bates GW. Postoperative effects of fentanyl, ketorolac, and piroxicam as analgesics for outpatient laparoscopic procedures. Journal of Obstetrics and Gynecology 1994;83(2):270‐5. - PubMed
Marcucci 1991 {published data only}
    1. Marcucci M, Panelli G, Cambini S. Clinical experience in the treatment of dental pain. The Clinical Journal of Pain 1991;7 (suppl):S72‐6. - PubMed
Massart 1986 {published data only}
    1. Massart P, Bezes H. Comparison of the efficacy and tolerance of isoxicm and piroxicam following surgery for ski‐ing accidents. British Journal of Clinical Pharmacology 1986;22:161S‐5S. - PMC - PubMed
Meisel 1986 {published data only}
    1. Meisel AD. Clinical benefits and comparative safety of piroxicam. Analysis of worldwide clinical trials data. The American Journal of Medicine 1986;81(5B):15‐21. - PubMed
Melzsack 1985 {published data only}
    1. Melzsack R, Bentley K, Jeans ME. Piroxicam versus acetaminophen and placebo for the relief of postoperative dental pain. Current Therapeutic Research 1985;37:1134‐40.
Michelacci 1990 {published data only}
    1. Michelacci M, Boscarino G, Acerbi D, Bufalino L, Gardini F. Analgesic effect and pharmacokinetics of a piroxicam beta‐cyclodextrin oral formulation in post‐surgical pain: A controlled study versus an injectable piroxicam formulation. Clinical Trials Journal 1990;27(3):176‐86.
Mogensen 1990 {published data only}
    1. Mogensen T, Vegger P, Jonsson T, Matzke AE, Lund C, Kehlet H. Systemic piroxicam as an adjunct to combined epidural bupivacaine and morphine for postoperative pain ‐ a double‐blind study. Pain 1990;S138:S138. - PubMed
Mogensen 1992 {published data only}
    1. Mogensen T, Vegger P, Jonsson T, Matzke AE, Lund C, Kehlet H. Systemic piroxicam as an adjunct to combined epidural bupivacaine and morphine for postoperative pain relief ‐ a double‐blind study. Anesthesia and Analgesia 1992;74:366‐70. - PubMed
Moiniche 1994 {published data only}
    1. Moiniche S, Hjortso NC, Hansen BL, Dahl JB, Rosenberg J, Gebuhr P, et al. The effect of balanced analgesia on early convalescence after major orthopaedic surgery. Acta Anaesthesiologica Scandinavica 1994;38(4):328‐35. - PubMed
Moraes 1991 {published data only}
    1. Moraes MF, Antonini RA. Use of piroxicam im in buccomaxillofacial surgery. Folha Medica 1991;102(1‐2):39‐43.
Morrow 1995 {published data only}
    1. Morrow BC, Milligan KR, Murthy BV. Analgesia following day‐case knee arthroscopy ‐ the effect of piroxicam with or without bupivacaine infiltration. Anaesthesia 1995;50(5):461‐3. - PubMed
Negm 1989 {published data only}
    1. Negm MM. Management of endodontic pain with nonsteroidal anti inflammatory agents: a double blind, placebo controlled study. Oral Surgery, Oral Medicine, and Oral Pathology 1989;67(1):88‐95. - PubMed
Negm 1994 {published data only}
    1. Negm MM. Effect of intracanal use of nonsteroidal anti‐inflammatory agents on post treatment endodontic pain. Oral Surgery, Oral Medicine, and Oral Pathology 1994;77(5):507‐13. - PubMed
Nelson 1986 {published data only}
    1. Nelson SL, Bergman SA. Double‐blind, parallel study of the efficacy and safety of piroxicam in the relief of post‐operative pain following dental extraction. Clinical Pharmacology and Therapeutics 1986;39(2):216.
Nelson 1987 {published data only}
    1. Nelson SL, Brahim J, Treglown S. Double blind study of piroxicam (2 doses), Aspirin and placebo in patients with postoperative dental pain. Clinical Pharmacology and Therapeutics 1987;41(2):182.
O'Hanlon 1996a {published data only}
    1. O'Hanlon JJ, Beers H, Huss BK, Milligan KR. A comparison of the effect of intramuscular diclofenac, ketorolac or piroxicam on post‐operative pain following laparoscopy. European Journal of Anaesthesiology 1996;13(4):404‐7. - PubMed
O'Hanlon 1996b {published data only}
    1. O'Hanlon JJ, McCleane G, Muldoon T. Preoperative application of piroxicam gel compared to a local anaesthetic field block for postoperative analgesia. Acta Anaesthesiologica Scandinavica 1996;40(6):715‐8. - PubMed
O'Hanlon 1996c {published data only}
    1. O'Hanlon JJ, Muldoon T, Lowry D, McCleane G. Improved postoperative analgesia with preoperative piroxicam. Canadian Journal of Anaesthesia 1996;43(2):102‐5. - PubMed
Ogunbode 1987 {published data only}
    1. Ogunbode O. A comparative trial of piroxicam and paracetamol after episiotomy wound repair. Current Therapeutic Research, Clinical and Experimental 1987;41(1):89‐94.
Ohnishi 1981 {published data only}
    1. Ohnishi MH. The clinical effect of piroxicam on postexodontic or postoperative pain ‐ a double blind study. Japanese Journal of Oral Surgery 1981;27:532‐40.
Ohnishi 1983a {published data only}
    1. Ohnishi M, Kawai T, Ogawa N. Double blind evaluation of piroxicam and indomethacin in the treatment of inflammation following oral surgery. European Journal of Rheumatology and Inflammation 1983;6(3):259‐65. - PubMed
Ohnishi 1983b {published data only}
    1. Ohnishi M, Kawai T, Ogawa N. Double‐blind comparison of piroxicam and mefanamic acid in the treatment of oral surgical pain. European Journal of Rheumatology and Inflammation 1983;6(3):253‐8. - PubMed
Olson 1987 {published data only}
    1. Olson N, Sunshine A, Marrero I, Ramos I, Laska E. Piroxicam, aspirin and placebo in dental pain. Clinical Pharmacology and Therapeutics 1987;41(2):162.
Parsloe 1988 {published data only}
    1. Parsloe M, Chater SN, Bembridge M, Simpson KH. Premedication with piroxicam in patients having dental surgery under general anaesthesia with halothane or isoflurane. British Journal of Anaesthesia 1988;61(6):702‐6. - PubMed
Pase 1986 {published data only}
    1. Pase U. Use of piroxicam in dentistry. Giornale di Stomatologia e di Ortognatodonzia 1986;1:67‐8. - PubMed
Patel 1996 {published data only}
    1. Patel RK, Leswell PF. Comparison of ketoprofen, piroxicam, and diclofenac gels in the treatment of acute soft‐tissue injury in general practice. General Practice Study Group. Clinical Therapeutics 1996;18(3):497‐507. - PubMed
Piironen 1985 {published data only}
    1. Piironen J, Sjoblad AM, Oikarinen VJ. The analgesic efficacy of one preoperative and postoperative dose of piroxicam in oral surgery. Proceedings Of The Finnish Dental Society 1985;81(5‐6):271‐4. - PubMed
Roelofse 1996 {published data only}
    1. Roelofse JA, Swart LC, Stander IA. An observer‐blind randomised parallel group study comparing the efficacy and tolerability of tenoxicam and piroxicam in the treatment of post‐operative pain after oral surgery. The Journal of the Dental Association of South Africa 1996;51(11):707‐11. - PubMed
Selcuk 1998 {published data only}
    1. Selcuk E, Gomel M, Apaydin S, Kose T, Tuglular I. The postoperative analgesic efficacy and safety of piroxicam (FDDF) and naproxen sodium. International Journal of Clinical Pharmacology Research 1998;18(1):21‐9. - PubMed
Sencift 1997 {published data only}
    1. Sencift K, Akkocaoglu M, Turkes O, Araz K. The clinical effects of fast dissolving dosage form of piroxicam in impacted third molar surgery. The Journal of The Turkish Society of Algology 1997;9(1):13‐7.
Serpell 1989 {published data only}
    1. Serpell MG, Thomson MF. Comparison of piroxicam with placebo in the management of pain after total hip replacement. British Journal of Anaesthesia 1989;63(3):354‐6. - PubMed
Simone 1990 {published data only}
    1. Simone C, Oliani C. Beta‐cyclodextrin‐piroxicam: Efficacy and tolerability in the treatment of pain after bone and joint surgery. Current Therapeutic Research, Clinical and Experimental 1990;47(3):541‐7.
Singson‐Alday 1984 {published data only}
    1. Singson‐Alday. A study of the analgesic activity of piroxicam (feldene) in patients with post episiotomy pain. Current Therapeutic Research 1984;36:1261‐8.
Sunshine 1995a {published data only}
    1. Sunshine A, Marrero I, Mcmoemick N, Lawrence V, Gafney M, Ackert P. The analgesic efficacy of piroxicam, aspirin and placebo in postoperative oral surgery pain. Clinical Pharmacology and Therapeutics 1995;37(2):232.
Sunshine 1995b {published data only}
    1. Sunshine A. Analgesia induced by oral NSAIDs: Issues of relative efficacy. European Journal of Rheumatology and Inflammation 1995;15(2):19‐26.
Taboada 1992 {published data only}
    1. Taboada A. Not available [Experienca controlada con gel de piroxicam asociado a ultrasonidos en afecciones agudas del aparto locomotor]. Prensa Medica Argentina 1992;79:630‐2.
Teixeira 1993 {published data only}
    1. Teixeira F, Porto A, Moura J. Efficacy of a single daily dose of a nonsteroidal anti‐inflammatory drug with an intermediate plasma half‐life: A double‐blind, comparative trial of acemetacin and piroxicam. Current Therapeutic Research 1993;53(1):103‐12.
Utsunomiya 1983 {published data only}
    1. Utsunomiya Y, Sotoike H, Shirosawa T, Kamata N, Omori N. [Analgesic effect of Feldene (piroxicam) on pain following minor oral surgery]. Shikai Tenbo = Dental outlook 1983;62(4):835‐9. - PubMed
Vagnoni 1990 {published data only}
    1. Vagnoni S, Rodola F, Stancanelli V, Barbi S, Mascaro A, Camaioni D. Postoperative analgesia in open‐chest surgery. Ortopedia e Traumatologia Oggi 1990;10(6):369‐76.
Van Lackner 1996 {published data only}
    1. Lancker P, Devulder J, Rolly G. Systemic piroxicam as an adjunct to patient‐controlled analgesia with alfentanil for postoperative pain relief. Anaesthesia 1996;51(7):658‐62. - PubMed
Wakeling 1996 {published data only}
    1. Wakeling HG, Creagh Barry P, Butler PJ. Postoperative analgesia in dental day case surgery. Comparison between Feldene 'Melt' (piroxicam) and diclofenac suppositories. Anaesthesia 1996;51(8):784‐6. - PubMed
Yagi 1997 {published data only}
    1. Yagi Y, Sakaguchi H, Noda M, et al. Postoperative pain management after head and neck surgery. Journal of Japanese Dental Society of Anesthesiology 1997;25(2):163‐8.
Yoshimasu 1983 {published data only}
    1. Yoshimasu H, Yoshikane K, Nakano Y, Iwata J, Yokoo E. [An anti‐inflammatory analgesic, Feldene (piroxicam), for pain following tooth extraction ‐ clinical results]. Shikai Tenbo = Dental outlook 1983;62(4):829‐34. - PubMed

Additional references

Barden 2004
    1. Barden J, Edwards JE, McQuay HJ, Wiffen PJ, Moore RA. Relative efficacy of oral analgesics after third molar extraction. British Dental Journal 2004;197(7):407‐11. - PubMed
Collins 1997
    1. Collins SL, Moore RA, McQuay HJ. The visual analogue pain intensity scale: what is moderate pain in millimetres?. Pain 1997;72:95‐7. - PubMed
Collins 1998
    1. Collins SL, Edwards J, Moore A, McQuay HJ. Single dose dextropropoxyphene in postoperative pain: a quantitative systematic review. European Journal of Clinical Pharmacology 1998;54:107‐12. - PubMed
Collins 1999
    1. Collins SL, Moore RA, McQuay HJ, Wiffen PJ, Edwards JE. Single dose oral ibuprofen and diclofenac for postoperative pain. Cochrane Database of Systematic Reviews 1999, Issue 4. [DOI: 10.1002/14651858.CD001548] - DOI - PubMed
Cook 1995
    1. Cook RJ, Sackett DL. The number needed to treat: a clinically useful measure of treatment effect. British Medical Journal 1995;310:452‐4. - PMC - PubMed
Edwards 1999
    1. Edwards JE, McQuay HJ, Moore RA, Collins SL. Reporting of adverse effects in clinical trials should be improved: lessons from acute postoperative pain. Journal of Pain and Symptom Management 1999;18(6):427‐37. - PubMed
Hardman 1996
    1. Hardman JG, Gilman AG, Limbird LE. Goodman & Gilman's 'The Pharmacological Basis of Therapeutics'. Ninth. New York: McGraw Hill, 1996:617‐57.
Jadad 1996a
    1. Jadad AR, Carroll D, Moore A, McQuay HJ. Developing a database of published reports of randomised clinical trials in pain research. Pain 1996;66:239‐46. - PubMed
Jadad 1996b
    1. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Controlled Clinical Trials 1996;17:1‐12. - PubMed
Lasagna 1962
    1. Lasagna L. The psychophysics of clinical pain. Lancet 1962;2:572‐5. - PubMed
McQuay 1998
    1. McQuay HJ, Moore RA. An evidence‐based resource for pain relief. Oxford: Oxford University Press, 1998.
Moore 1996
    1. Moore A, McQuay H, Gavaghan D. Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics. Pain 1996;66(2‐3):229‐37. - PubMed
Moore 1997a
    1. Moore A, McQuay H, Gavaghan D. Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics. Verification from independent data. Pain 1997;69(1‐2):127‐30. - PubMed
Moore 1997b
    1. Moore A, Moore O, McQuay H, Gavaghan D. Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics: Use of pain intensity and visual analogue scales. Pain 1997;69(3):311‐5. - PubMed
Moore 1997c
    1. Moore RA, Collins SL, Caroll D, McQuay HJ. Paracetamol with and without codeine in acute pain: a quantitative systematic review. Pain 1997;70:193‐201. - PubMed
Moore 1997d
    1. Moore RA, McQuay HJ. Single‐patient data meta‐analysis of 3453 postoperative patients: Oral tramadol versus placebo, codeine and combination analgesics. Pain 1997;69(3):287‐94. - PubMed
Morris 1995
    1. Morris JA, Gardner MJ. Calculating confidence intervals for relative risk, odds ratios and standardised ratios and rates. In: Gardner MJ, Altman DG editor(s). Statistics with confidence ‐ confidence intervals and statistical guidelines. London: British Medical Journal, 1995:50‐63. - PMC - PubMed
PACT 2006
    1. Anonymous. Prescription Cost Analysis, England 2006. ISBN: 1‐84636‐035‐6 2006.

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