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. 1976 Nov 26;117(2):287-95.
doi: 10.1016/0006-8993(76)90736-8.

Effect of surgical isolation of the hypothalamus on its neurotransmitter content

M J Brownstein, M Palkovits, M L Tappaz, J M Saavedra, J S Kizer

Effect of surgical isolation of the hypothalamus on its neurotransmitter content

M J Brownstein et al. Brain Res. .

Abstract

The concentrations of norepinephrine, dopamine-beta-hydroxylase, dopamine, tyrosine hydroxylase, phenylethanolamine-N-methyltransferase, serotonin, tryptophan hydroxylase, histamine, glutamic acid decarboxylase, and choline acetyltransferase were determined in selected hypothalamic nuclei and in the median eminence after deafferentation of the medial basal hypothalamus. Norepinephrine and dopamine-beta-hydroxylase fell markedly while dopamine and tyrosine hydroxylase did not. Serotonin also decreased in all regions studied; histamine decreased in none. Choline acetyltransferase, phenylethanolamine-N-methyltransferase, and glutamic acid decarboxylase declined in some areas, but not in others.

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