doi: 10.1128/AAC.44.11.3174-3176.2000.
Postantibiotic leukocyte enhancement of meropenem against gram-positive and gram-negative strains
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- PMID: 11036045
- PMCID: PMC101625
- DOI: 10.1128/AAC.44.11.3174-3176.2000
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Postantibiotic leukocyte enhancement of meropenem against gram-positive and gram-negative strains
Antimicrob Agents Chemother.
2000 Nov.
Abstract
The postantibiotic leukocyte enhancement (PALE) of meropenem in vitro in comparison with that of imipenem was evaluated with 24 recently isolated gram-positive and gram-negative strains. In general, pre-exposure to carbapenems (at four times the MIC for 2 h) led to increased polymorphonuclear cell phagocytic killing. The PALE of imipenem was generally significantly less than that observed with meropenem.
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