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. 2000 Nov;44(11):3174-6.
doi: 10.1128/AAC.44.11.3174-3176.2000.

Postantibiotic leukocyte enhancement of meropenem against gram-positive and gram-negative strains

A Novelli  1 , S Fallani, M I Cassetta, S Conti, T Mazzei
Affiliations

Postantibiotic leukocyte enhancement of meropenem against gram-positive and gram-negative strains

A Novelli et al. Antimicrob Agents Chemother. 2000 Nov.

Abstract

The postantibiotic leukocyte enhancement (PALE) of meropenem in vitro in comparison with that of imipenem was evaluated with 24 recently isolated gram-positive and gram-negative strains. In general, pre-exposure to carbapenems (at four times the MIC for 2 h) led to increased polymorphonuclear cell phagocytic killing. The PALE of imipenem was generally significantly less than that observed with meropenem.

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