A 1998 survey of extended-spectrum beta-lactamases in Enterobacteriaceae in France. The French Study Group

Abstract

In a 3-month period in 1998, 79 consecutive isolates of Enterobacteriaceae producing an extended-spectrum beta-lactamase (ESBL) were collected. ESBLs were predominantly TEM derivatives (74 of 79): TEM-24-like (40 isolates), TEM-3-like (29 isolates), TEM-21 (3 isolates), and TEM-4 and TEM-52 (1 isolate each). Four isolates produced SHV derivatives SHV-4 (three isolates) and SHV-5 (one isolate), and one strain produced a CTX-M-3 enzyme. The high proportion of TEM-24-like-producing Enterobacter aerogenes isolates (36 of 79) suggests the occurrence of an epidemic strain in France.

FIG. 1

Distribution of ESBL-producing strains among regions and centers. ●, TEM-24-like; ▴, TEM-3-like; ▪, others (TEM-21, SHV-4-like, TEM-52, SHV-5, CTX-M-3, TEM-4). Numbers in parentheses are numbers of isolates in which enzymes were found. Regions (cities where study hospitals are located are in parentheses [see Appendix for respective French Study Group members]): R1, Nord and Pas-de-Calais (Lille and Valenciennes); R2, Ile-de-France (Créteil and Versailles); R3, Champagne and Ardennes (Troyes); R4, Alsace-Lorraine (Mulhouse); R5, Brittany (Rennes); R6, Pays-de-Loire (Le Mans); R7, Auvergne (Clermont-Ferrand); Rhone-Alps (Lyon); R9 Midi-Pyrenees (Toulouse); R10, Languedoc-Roussillon (Perpignan); R11, Provence, Alps, and Côte d'Azur (Nice and Aix-en-Provence).