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. 2000 Nov;44(11):3217-9.
doi: 10.1128/AAC.44.11.3217-3219.2000.

Effect of ceftazidime on systemic cytokine concentrations in rats

K M Alkharfy  1 , J A Kellum, R F Frye, G R Matzke
Affiliations

Effect of ceftazidime on systemic cytokine concentrations in rats

K M Alkharfy et al. Antimicrob Agents Chemother. 2000 Nov.

Abstract

The effect of a single dose of ceftazidime on circulating concentrations of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) in a rat model of sepsis was studied. IL-6 concentrations were significantly elevated (100 to 200 times the baseline) 6 h after ceftazidime administration in both septic and nonseptic (control) rats. TNF-alpha concentrations increased significantly in nonseptic (approximately 40 times the baseline) rats but not septic (approximately 2 to 3 times the baseline) rats. Ceftazidime administration was not associated with an increase in endotoxin concentrations. These findings suggest that ceftazidime modulation of proinflammatory cytokine concentrations may be independent of its antimicrobial properties.

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Figures

FIG. 1
FIG. 1
Systemic IL-6 concentrations are significantly elevated after ceftazidime administration to CLP rats (group A) or healthy rats (group B) but not in the CLP rats that did not receive ceftazidime (group C) (P < 0.001). ∗, P < 0.001 versus CLP; #, P < 0.001 versus CLP; CTZ, ceftazidime.
FIG. 2
FIG. 2
Healthy rats that received a 30-mg/kg ceftazidime intravenous bolus (group B) had a significantly greater change in concentrations of TNF-α than did CLP rats that did not receive CTZ (group C). ∗, P < 0.05 versus CLP. An increase in TNF-α concentrations was also noted in the CLP rats that received ceftazidime (group A). This increase, however, did not achieve statistical significance. CTZ, ceftazidime.
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