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. 2000 Oct 27;881(2):241-3.
doi: 10.1016/s0006-8993(00)02847-x.

Plasma cortisol levels in elderly female subjects with Alzheimer's disease: a cross-sectional and longitudinal study

H Umegaki  1 , H Ikari, H Nakahata, H Endo, Y Suzuki, O Ogawa, A Nakamura, T Yamamoto, A Iguchi
Affiliations

Plasma cortisol levels in elderly female subjects with Alzheimer's disease: a cross-sectional and longitudinal study

H Umegaki et al. Brain Res. .

Abstract

We investigated the plasma cortisol levels at a fasting state in elderly female Alzheimer's disease (AD), vascular dementia (VD), and non-demented subjects (n=66, 28 and 21, respectively). Twenty-eight AD subjects were followed for 40 months. The plasma cortisol levels in AD and VD subjects were significantly higher than those of non-demented subjects at baseline. In AD subjects in relatively early stages of the disease [Mini-Mental State Examination (MMSE)], at baseline, high plasma cortisol led to rapid declines in MMSE scores over a 40-month period.

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