Review
doi: 10.1097/00001813-200008000-00002.
The clinical pharmacology of alkylating agents in high-dose chemotherapy
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- PMID: 11036954
- DOI: 10.1097/00001813-200008000-00002
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Review
The clinical pharmacology of alkylating agents in high-dose chemotherapy
Anticancer Drugs.
2000 Aug.
Abstract
Alkylating agents are widely used in high-dose chemotherapy regimens in combination with hematological support. Knowledge about the pharmacokinetics and pharmacodynamics of these agents administered in high doses is critical for the safe and efficient use of these regimens. The aim of this review is to summarize the clinical pharmacology of the alkylating agents (including the platinum compounds) in high-dose chemotherapy. Differences between conventional and high doses will be discussed.
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