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Comparative Study
. 1975 Sep 12;253(2):113-8.
doi: 10.1007/BF00582063.

Inhibition of glucose-6-phosphate dehydrogenase activity by betamethasone and three of its esters with dermatological importance

W P Raab, B M Gmeiner
Comparative Study

Inhibition of glucose-6-phosphate dehydrogenase activity by betamethasone and three of its esters with dermatological importance

W P Raab et al. Arch Dermatol Res (1975). .

Abstract

Betamethasone, betamethasone-17-valerate, betamethasone-17-benzoate, and betamethasone-17,21-diproprionate were investigated for their inhbitory action on glucose-beta-phosphate dehydrogenase (G-6-PDH) activity (pure enzyme from yeast, enzyme from human skin homogenate). Between these four compounds, marked differences were encountered which could not be attributed to the presence of an esterified or unesterified steroid. According to these data it does not seem to be justified to consider betamethasone esters simply as the transport forms of the topically inactive betamethasone but one must consider the betamethasone esters having biochemical actions of their own.

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References

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    1. Curr Ther Res Clin Exp. 1974 Aug;16(8):798-803 - PubMed
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    1. Curr Ther Res Clin Exp. 1973 May;15(5):243-7 - PubMed
    1. Br J Dermatol. 1974 Jan;90(1):85-90 - PubMed

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