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. 2000 Oct;20(10):792-4.

The influence of parity and gravidity on first trimester markers of chromosomal abnormality

K Spencer  1 , C Y Ong, A W Liao, K H Nicolaides
Affiliations
  • PMID: 11038455

The influence of parity and gravidity on first trimester markers of chromosomal abnormality

K Spencer et al. Prenat Diagn. 2000 Oct.

Abstract

We have studied changes in first trimester fetal nuchal translucency (NT) and maternal serum free beta-hCG and PAPP-A with gravidity and parity in 3252 singleton pregnancies unaffected by chromosomal abnormality or major pregnancy complications. We have shown that gravidity and parity is associated with a small but progressive decrease in fetal NT and a small but progressive increase in free beta-hCG and PAPP-A. None of these small changes with increasing gravidity or parity are statistically significant and hence correction for these variables is not necessary when considering first trimester screening for chromosomal abnormalities.

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