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Review
. 1975 Jul-Aug;70(4):456-66.
doi: 10.1007/BF01914341.

Genetics of patent ductus arteriosus

A S Cascos, J M Sagredo
Review

Genetics of patent ductus arteriosus

A S Cascos et al. Basic Res Cardiol. 1975 Jul-Aug.

Abstract

A genetic study of 119 correlative cases of patent ductus arteriosus has been performed. The isolated cases showed female predominance, but there was a three times higher risk for the sibs of male cases, suggesting a multifactorial causative mechanism. Dermatoglyphs presented an excess of arches in male, and a tendency to distal axial triradius in female. There were 15 cases belonging to polymalformative syndromes, such as mongolism, Turner, Noonan, Holt-Oram, Lewis and rubella embryopathy.

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