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. 1975 Dec 16;14(25):5529-34.
doi: 10.1021/bi00696a023.

Studies on the cooperative binding of the Escherichia coli DNA unwinding protein to single-stranded DNA

W T Ruyechan, J G Wetmur

Studies on the cooperative binding of the Escherichia coli DNA unwinding protein to single-stranded DNA

W T Ruyechan et al. Biochemistry. .

Abstract

The cooperative binding of the Escherichia coli DNA unwinding protein to single-stranded DNA has been studied by electron microscopy. Analysis of the electron microscopic data by means of a simple statistical mechanical model has yielded a value of 3.8-7.6 X 10(10) l./mol for the cooperative binding constant in 0.15 M NaCl. Studied under elevated salt conditions have shown that the average DNA protein complex length is 50% of the length found at 0.04 or 0.15 M NaCl.

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