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. 2000 Oct 20;406(3):341-3.
doi: 10.1016/s0014-2999(00)00693-2.

Effects of fluoroquinolones on HERG currents

U Bischoff  1 , C Schmidt, R Netzer, O Pongs
Affiliations

Effects of fluoroquinolones on HERG currents

U Bischoff et al. Eur J Pharmacol. .

Abstract

We have investigated the effects of four fluoroquinolones on the human ether-à-go-go-related gene (HERG) mediated K(+) currents to evaluate their potential to induce QT-prolongation. HERG currents were measured from stably transfected Chinese hamster ovary (CHO) cells by means of the patch-clamp technique. Bath application of sparfloxacin, moxifloxacin and grepafloxacin produced an inhibition of HERG outward currents at -40 mV with EC(50) of 13.5+/-0.8, 41. 2+/-2.0 and 37.5+/-3.3 microg/ml, respectively. Current inhibitions were reversible after washout of the compounds. By contrast, ciprofloxacin at concentrations of up to 100 microg/ml did not effect HERG outward currents.

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