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. 1979 Apr 17;27(2):161-4.
doi: 10.1007/BF02441179.

Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy

J U Lindgren, T S Lindholm

Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy

J U Lindgren et al. Calcif Tissue Int. .

Abstract

Fifty adult female rats were used to study the effect of 1-alpha-hydroxyvitamin D3 (1alpha-OH-D3) on bone after oophorectomy. The experimental period was 6 months. At the end of the experiment the femurs and the tibias were investigated for bone mass and composition. Significant signs of osteopenia occurred as a result of oophorectomy. The treatment with 1alpha-OH-D3 induced only minor changes in blood chemistry but increased bone mass significantly. The findings support the view that 1alpha-OH-D3 may be a valuable tool in the treatment of osteoporosis resulting from ovarian insufficiency.

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