Review
doi: 10.1016/s1043-2760(00)00305-2.
Life and death of the pancreatic beta cells
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- PMID: 11042468
- DOI: 10.1016/s1043-2760(00)00305-2
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Review
Life and death of the pancreatic beta cells
Trends Endocrinol Metab.
2000 Nov.
Abstract
Pancreatic beta cells are responsible for maintaining the body's glucose levels within a very narrow range; their population is dynamic, with compensatory changes to maintain euglycemia. Throughout the lifetime of a mammal, low levels of beta-cell replication and apoptosis are balanced and result in a slowly increasing mass of beta cells. The emphasis in this review is on recent insights on the natural history of the beta cell in a normal pancreas: sources of renewal, survival and changes in differentiation.
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