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Review
. 2000 Oct;8(10):452-6.
doi: 10.1016/s0966-842x(00)01845-x.

The Toll receptor family and microbial recognition

R Medzhitov  1 , C Janeway Jr
Affiliations
Free article
Review

The Toll receptor family and microbial recognition

R Medzhitov et al. Trends Microbiol. 2000 Oct.
Free article

Abstract

The survival of multicellular organisms is dependent on their ability to recognize invading microbial pathogens and to induce a variety of defense reactions. Recent evidence suggests that an evolutionarily ancient family of Toll-like receptors plays a crucial role in the detection of microbial infection and the induction of immune and inflammatory responses.

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