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. 1975;6(3-4):213-6.

A technique for intensifying BCG sensitivity

S R Parmett, E Klein
  • PMID: 1104733

A technique for intensifying BCG sensitivity

S R Parmett et al. J Med. 1975.

Abstract

Sensitization to BCG (Bacille Calmette-Guérin) appears to be more effective when it is carried out at the site of a delayed hypersensitivity challenge reaction to DNCB (1-chloro, 2,4-dinitrobenzene) than when it is carried out at unchallenged sites in non-sensitized animals. The effectiveness of BCG sensitization was determined by measurement of the intensity of the PPD (Purified Protein Derivative of tuberculin) 24-hour skin test. Possible mechanisms for this phenomenon and its implications for cancer immunotherapy are considered.

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