doi: 10.1084/jem.142.6.1564.
Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control
- PMID: 1104749
- PMCID: PMC2190064
- DOI: 10.1084/jem.142.6.1564
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Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control
J Exp Med.
.
Abstract
Experimental amyloidosis in mice can be induced by repeated injections of casein. It has now been demonstrated that casein induces strong polyclonal antibody synthesis in mouse B spleen lymphocytes. This effect is much more pronounced in spleen cells from anyloid-susceptible mice (CBA/J) than amyloid-resistant mice (A/J). It is suggested that amyloidosis can be due in some instances to a constant exposure for molecules which induce polyclonal B-cell activation.
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