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Clinical Trial
. 2000 Jul-Aug;9(4):197-200.
doi: 10.1002/1520-6661(200007/08)9:4<197::AID-MFM1>3.0.CO;2-0.

Effect of low-sodium diet on uteroplacental circulation

F M Delemarre  1 , L A van Leest, H W Jongsma, E A Steegers
Affiliations
Clinical Trial

Effect of low-sodium diet on uteroplacental circulation

F M Delemarre et al. J Matern Fetal Med. 2000 Jul-Aug.

Abstract

Objective: To study the influence of chronic dietary sodium restriction on uteroplacental circulation.

Methods: In a randomized trial, Doppler flow velocity waveforms of the uterine and umbilical artery were studied at monthly intervals during pregnancy in 59 women on a low-sodium diet and in 68 controls.

Results: Pulsatility index (PI), resistance index (RI), and A/B ratio of the uterine artery were significantly lower during sodium restriction, whereas PI, RI, and A/B ratio of the umbilical artery were significantly higher.

Conclusions: The lower resistance indices of the uterine artery during sodium restriction might reflect an increase in pulse pressure/impedance ratio as a result of activation of the renin-angiotensin system. The increase in umbilical artery resistance indices supports the hypothesis that fetal circulation might be altered by chronic dietary sodium restriction.

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