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Clinical Trial
. 2000 Oct;31(4):1104-7.
doi: 10.1086/318121.

Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic

S Sundar  1 , D K More, M K Singh, V P Singh, S Sharma, A Makharia, P C Kumar, H W Murray
Affiliations
Clinical Trial

Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic

S Sundar et al. Clin Infect Dis. 2000 Oct.

Abstract

In India, 320 patients with visceral leishmaniasis (209 in the state of Bihar and 11 in the neighboring state of Uttar Pradesh) received identical pentavalent antimony (Sb) treatment. Sb induced long-term cure in 35% (95% confidence interval [CI], 28%-42%) of those in Bihar versus 86% (95% CI, 79%-93%) of those in Uttar Pradesh. In Bihar, the center of the Indian epidemic, traditional Sb treatment should be abandoned.

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