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. 2000 Oct 16;10(20):2247-50.
doi: 10.1016/s0960-894x(00)00457-1.

Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists

Y Wang  1 , S Chackalamannil, Z Hu, J W Clader, W Greenlee, W Billard, H Binch, G Crosby, V Ruperto, R A Duffy, R McQuade, J E Lachowicz
Affiliations

Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists

Y Wang et al. Bioorg Med Chem Lett. .

Abstract

Identification of a number of highly potent M2 receptor antagonists with >100-fold selectivity against the M1 and M3 receptor subtypes is described. In the rat microdialysis assay, this series of compounds showed pronounced enhancement of brain acetylcholine release after oral administration.

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