Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Dec 4;12(4):315-20.
doi: 10.1007/BF01323419.

Influence of energy metabolism on the repair of x-ray damage in living cells. IV. Effects of 2-deoxy-D-glucose on the repair phenomena during fractionated irradiation of yeast

V K Jain, W Pohlit, S C Purohit

Influence of energy metabolism on the repair of x-ray damage in living cells. IV. Effects of 2-deoxy-D-glucose on the repair phenomena during fractionated irradiation of yeast

V K Jain et al. Radiat Environ Biophys. .

Abstract

Inhibition of repair of sublethal and potentially lethal damage was observed in respiratory-deficient mutants of yeast during fractionated X-irradiation in the presence of equimolar concentrations of 2-deoxy-D-glucose and glucose in the growth medium. In the wild-type cells, on the other hand, an enhancement of repair of the potentially lethal damage was obtained under similar conditions. These results suggest, by analogy, that in higher organisms also, 2-deoxy-D-glucose may differentially inhibit the repair of radiation damage in hypoxic tumor cells while enhancement of repair processes could be expected in normal tissues.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Cancer Res. 1974 Feb;34(2):351-4 - PubMed
    1. Biochim Biophys Acta. 1968 Nov 5;163(3):386-94 - PubMed
    1. Nature. 1959 Oct 24;184:1293-5 - PubMed
    1. Biophysik. 1973;10(2):137-42 - PubMed
    1. Biochim Biophys Acta. 1964 May 11;86:216-23 - PubMed