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. 1975 Dec 4;12(4):315-20.
doi: 10.1007/BF01323419.

Influence of energy metabolism on the repair of x-ray damage in living cells. IV. Effects of 2-deoxy-D-glucose on the repair phenomena during fractionated irradiation of yeast

V K Jain, W Pohlit, S C Purohit

Influence of energy metabolism on the repair of x-ray damage in living cells. IV. Effects of 2-deoxy-D-glucose on the repair phenomena during fractionated irradiation of yeast

V K Jain et al. Radiat Environ Biophys. .

Abstract

Inhibition of repair of sublethal and potentially lethal damage was observed in respiratory-deficient mutants of yeast during fractionated X-irradiation in the presence of equimolar concentrations of 2-deoxy-D-glucose and glucose in the growth medium. In the wild-type cells, on the other hand, an enhancement of repair of the potentially lethal damage was obtained under similar conditions. These results suggest, by analogy, that in higher organisms also, 2-deoxy-D-glucose may differentially inhibit the repair of radiation damage in hypoxic tumor cells while enhancement of repair processes could be expected in normal tissues.

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