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Clinical Trial
. 2000;4(4):249-254.
doi: 10.1186/cc701. Epub 2000 Jun 27.

Lack of agreement between tonometric and gastric juice partial carbon dioxide tension

A Dubin  1 , J Badie, S Fernandez, E Estenssoro, H Canales, G Bordoli, F Pálizas
Affiliations
Clinical Trial

Lack of agreement between tonometric and gastric juice partial carbon dioxide tension

A Dubin et al. Crit Care. 2000.

Abstract

STATEMENT OF FINDINGS: Our goal was to compare measurement of tonometered saline and gastric juice partial carbon dioxide tension (PCO2). In this prospective observational study, 112 pairs of measurements were simultaneously obtained under various hemodynamic conditions, in 15 critical care patients. Linear regression analysis showed a significant correlation between the two methods of measuring PCO2 (r(2) = 0.43; P < 0.0001). However, gastric juice PCO2 was systematically higher (mean difference 51 mmHg). The 95% limits of agreement were 315 mmHg and the dispersion increased as the values of PCO2 increased. Tonometric and gastric juice PCO2 cannot be used interchangeably. Gastric juice PCO2 measurement should be interpreted with caution.

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Figures

Figure 1
Figure 1
Correlation between gastric juice and tonometric PCO2. We performed 112 pairs of measurements of gastric juice and tonometric PCO2 in 15 critical care patients under different haemodynamic and oxygen transport conditions. The linear regression coefficient is significant. However, the slope value indicates systematic overestimation of gastric juice PCO2 in relation to saline PCO2.
Figure 2
Figure 2
Bland-Altman analysis of the differences between gastric juice and tonometric PCO2. The bias calculated as the mean difference of gastric juice and tonometric PCO2 was 51 mmHg. The 95% limits of agreement were 315 mmHg. The bias and the scattering of differences widened as PCO2 increased.
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Comment in

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