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. 2000 Nov 21;97(24):12957-8.
doi: 10.1073/pnas.210395797.

Polyglutamine disease and neuronal cell death

H L Paulson  1 , N M Bonini, K A Roth
Affiliations

Polyglutamine disease and neuronal cell death

H L Paulson et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Proposed model of early events in polyQ pathogenesis. Existing evidence suggests that CAG/polyQ expansion promotes the formation of a nonnative polyQ conformation. Shown are three major categories of downstream consequences that are not mutually exclusive and may be interdependent. How these or other consequences of a conformational change cause neuronal dysfunction and degeneration remains to be elucidated.
See this image and copyright information in PMC

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