Review
doi: 10.1038/80816.
Antibody regulation of B cell development
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- PMID: 11062496
- DOI: 10.1038/80816
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Review
Antibody regulation of B cell development
Nat Immunol.
2000 Nov.
Abstract
Antibodies on the surface of B lymphocytes trigger adaptive immune responses and control a series of antigen-independent checkpoints during B cell development. These physiologic processes are regulated by a complex of membrane immunoglobulin and two signal transducing proteins known as Ig alpha and Ig beta. Here we focus on the role of antibodies in governing the maturation of B cells from early antigen-independent through the final antigen-dependent stages.
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