Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2000 Oct 31;36(3):165-8.
doi: 10.1016/s0378-5122(00)00152-3.

Treatment of hot flushes with mirtazapine: four case reports

M D Waldinger  1 , H H Berendsen, D H Schweitzer
Affiliations
Case Reports

Treatment of hot flushes with mirtazapine: four case reports

M D Waldinger et al. Maturitas. .

Abstract

Objective: To evaluate the effect of mirtazapine on the severity of hot flushes and bouts of perspiration in women.

Method: In two women with depression a reduction in hot flushes was noticed by serendipity during treatment with mirtazapine 15-30 mg/daily. On the basis of this observation clinical studies were extended with two non-depressed and non-anxious women with hot flushes. Both subjects were prescribed mirtazapine daily.

Results: Four cases are described as case reports. All subjects reported a practically complete disappearance of hot flushes and associated perspiration, within the first week of treatment.

Conclusion: Mirtazapine appears to have a substantial ameliorating effect on hot flushes and perspiration bouts. It is postulated that the 5-HT(2A) blocking properties of mirtazapine is accounted in the symptomatic relief of hot flushes. In addition it is hypothesized that the serotonergic system is crucially involved in the pathogenesis of hot flushes and perspiration bouts. Further evaluation in double-blind placebo-controlled studies is encouraged.

PubMed Disclaimer

Publication types

LinkOut - more resources