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. 1975 Nov;25(11):1692-5.

[Synergism of colistin and sulfonamide in proteus species (author's transl)]

[Article in German]
  • PMID: 1106440

[Synergism of colistin and sulfonamide in proteus species (author's transl)]

[Article in German]
H H Kunz. Arzneimittelforschung. 1975 Nov.

Abstract

In agar diffusion testing of Proteus mirabilis strains sensitive to sulfonamide a synergistic effect of colistine (C) and sulfonamide (S) was demonstrated. By quantitative evaluation these results were confirmed in 100 strains of Proteus mirabilis and 100 strains of indol-positive Proteus spp. using broth dilution method. Combining 1 part C with 10 parts S the mean increase in sulfonamide sensitivity was enhanced fourfold. Increasing the inoculum sensitivity of Proteus against the combination of C and S was still found to range within therapeutic blood levels. Therefore in treatment of Proteus infection the positive synergistic effect of C+S should be taken into consideration.

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