Action of histamine on endothelial cells of guinea-pig isolated hepatic portal vein and its modification by indomethacin or removal of calcium
- PMID: 1106749
- PMCID: PMC2072717
Item in Clipboard
Action of histamine on endothelial cells of guinea-pig isolated hepatic portal vein and its modification by indomethacin or removal of calcium
Br J Exp Pathol.
1975 Feb.
Abstract
Methods are described for preparing guinea-pig hepatic portal vein endothelium for light microscopy and electron microscopy. Histamine (100 mug/ml) caused damage to the endothelium which was visible with both the light and electron microscopes. The damage was reduced in the absence of calcium. The reduction was more apparent with the electron microscope than with the light microscope. Indomethacin (100 mug/ml) protected the endothelial cells against the damaging effects of histamine. Possible modes of action of histamine and indomethacin are discussed.
Similar articles
-
Effect of anti-inflammatory drugs on the membrane potential of vascular endothelial cells in vitro.Br J Pharmacol. 1975 Jan;53(1):113-20. doi: 10.1111/j.1476-5381.1975.tb07337.x. Br J Pharmacol. 1975. PMID: 1125483 Free PMC article.
-
Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.J Pharmacol Exp Ther. 1975 Sep;194(3):554-64. J Pharmacol Exp Ther. 1975. PMID: 1159632
-
The dual action of meclofenamate on the contractile response to PGF2 alpha in the guinea-pig trachea.Pol J Pharmacol Pharm. 1975 May-Jun;27(3):273-6. Pol J Pharmacol Pharm. 1975. PMID: 238188
-
Antianaphylactic and antihistaminic activity of the non-steroidal anti-inflammatory compound nimesulide in guinea-pig.Arzneimittelforschung. 1990 Sep;40(9):1011-6. Arzneimittelforschung. 1990. PMID: 1981969
-
Development of histamine tachyphylaxis in the guinea-pig mesenteric artery.J Pharmacol Exp Ther. 1984 May;229(2):527-31. J Pharmacol Exp Ther. 1984. PMID: 6143819
Cited by
-
Possible involvement of microtubules in platelet-activating factor-induced increases in microvascular permeability in vitro.Inflammation. 1993 Dec;17(6):633-9. doi: 10.1007/BF00920470. Inflammation. 1993. PMID: 8112825
-
The effects of indomethacin and verapamil on the shape changes of vascular endothelial cells resulting from exposure to various inflammatory agents.Agents Actions. 1988 Jul;24(3-4):351-5. doi: 10.1007/BF02028293. Agents Actions. 1988. PMID: 3177095
-
Plasma exudation and asthma.Lung. 1988;166(1):1-23. doi: 10.1007/BF02714025. Lung. 1988. PMID: 3121940 Free PMC article. Review.
-
Histamine-induced inward currents in cultured endothelial cells from human umbilical vein.Br J Pharmacol. 1988 Oct;95(2):429-36. doi: 10.1111/j.1476-5381.1988.tb11663.x. Br J Pharmacol. 1988. PMID: 3147803 Free PMC article.
-
Effect of indomethacin and related drugs on the calcium ion-dependent secretion of lysosomal and other enzymes by neutrophil polymorphonuclear leucocytes in vitro.Br J Pharmacol. 1977 Feb;59(2):253-9. doi: 10.1111/j.1476-5381.1977.tb07487.x. Br J Pharmacol. 1977. PMID: 402167 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources