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Clinical Trial
. 1976 Jan;19(1):18-23.
doi: 10.1002/cpt197619118.

Assay of aspirin and naproxen analgesia

D L Mahler, W H Forrest Jr, C R Brown, P F Shroff, H E Gordon, B W Brown Jr, K E James
Clinical Trial

Assay of aspirin and naproxen analgesia

D L Mahler et al. Clin Pharmacol Ther. 1976 Jan.

Abstract

To establish the relative potency of naproxen and aspirin for oral analgesia, a 4-point, noncrossover bioassay with placebo control was undertaken with 197 patients. Subjective-response methods were used to determine two measures of postoperative analgesia over a period of 6 hr. With reasonable confidence for an oral analgesic assay, we found 220 mg of naproxen to be equivalent to 600 mg of aspirin for pain relief and 330 mg of naproxen to be equivalent to 600 mg of aspirin for decreased pain intensity.

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