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Comparative Study
. 2000 Dec;74(23):11422-5.
doi: 10.1128/jvi.74.23.11422-11425.2000.

CD4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5: comparison with responses to tegument and envelope glycoproteins

D M Koelle  1 , M Schomogyi, C McClurkan, S N Reymond, H B Chen
Affiliations
Comparative Study

CD4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5: comparison with responses to tegument and envelope glycoproteins

D M Koelle et al. J Virol. 2000 Dec.

Abstract

We used CD4 lymphocyte clones from herpes simplex virus type 2 (HSV-2) lesions or the cervix and molecular libraries of HSV-2 DNA to define HSV-2 major capsid protein VP5 and glycoprotein E (gE) as T-cell antigens. Responses to eight HSV-2 glycoprotein, tegument, nonstructural, or capsid antigens were compared in 19 donors. Recognition of VP5 and tegument VP22 were similar to that of gB2 and gD2, currently under study as vaccines. These prevalence data suggest that HSV capsid and tegument proteins may also be candidate vaccine antigens.

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Figures

FIG. 1
FIG. 1
Proliferative responses of HSV-2-stimulated PBMC lines for whole HSV-2 and defined HSV-2 antigens. Nineteen immunocompetent adults with symptomatic genital HSV-2 infection served as donors. Results are net Δcpm compared to mock virus (HSV-2), media (gB2, gD2, UL48), or lysates of cells transfected with empty vectors (other antigens). Data points with values of <102 are not visible.
FIG. 2
FIG. 2
Number of distinct HSV-2 protein antigens to which proliferative responses were detected in short-term PBMC lines from 19 HSV-2-infected adults.
See this image and copyright information in PMC

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