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. 2000 Nov 1;48(4):919-22.
doi: 10.1016/s0360-3016(00)00803-8.

Pancreatic tumors show high levels of hypoxia

A C Koong  1 , V K Mehta, Q T Le, G A Fisher, D J Terris, J M Brown, A J Bastidas, M Vierra
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Free article

Pancreatic tumors show high levels of hypoxia

A C Koong et al. Int J Radiat Oncol Biol Phys. .
Free article

Abstract

Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors.

Methods and materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode.

Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation.

Conclusion: Tumor hypoxia exists within pancreatic cancers.

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