A System for Identifying Genetic Networks from Gene Expression Patterns Produced by Gene Disruptions and Overexpressions

Abstract

A hot research topic in genomics is to analyze the interactions between genes by systematic gene disruptions and gene overexpressions. Based on a boolean network model without time delay, we have been investigating efficient strategies for identifying a genetic network by multiple gene disruptions and overexpressions. This paper first shows the relationship between our boolean network model without time delay and the standard synchronous boolean network model. Then we present a simulator of boolean networks without time delay for multiple gene disruptions and gene overexpressions, which includes a genetic network identifier with a graphic interface that generates instructions for experiments of gene disruptions and overexpressions.