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Case Reports
. 1976 Jan;30(4-5):377-83.

Response to LH-RH and HCG in two brothers with the Reifenstein syndrome

E Flatau, Z Josefsberg, R Prager-Lewin, E Markman-Halabe, H Kaufman, Z Laron
  • PMID: 1107277
Case Reports

Response to LH-RH and HCG in two brothers with the Reifenstein syndrome

E Flatau et al. Helv Paediatr Acta. 1976 Jan.

Abstract

Two brothers with Reifenstein syndrome underwent LH-RH and HCG tests at various ages ranging from 13 to 17 years. We found that at age 13 the plasma LH and FSH response to one LH-RH injection was normal. After the age of 14, the basal plasma concentration of LH and FSH and their response to LH-RH became elevated. Concomitantly the plasma testosterone levels rose to abnormal levels. These findings are compatible with progressive development of primary gonadal dysfunction and with peripheral insensitivity to testosterone.

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