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Review
. 2000 Dec;20(23):8635-42.
doi: 10.1128/MCB.20.23.8635-8642.2000.

Upstream open reading frames as regulators of mRNA translation

Affiliations
Review

Upstream open reading frames as regulators of mRNA translation

D R Morris et al. Mol Cell Biol. 2000 Dec.
No abstract available

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Figures

FIG. 1
FIG. 1
Alternative fates available to a ribosome after translating a uORF. See the text for a detailed discussion.
FIG. 2
FIG. 2
Structures of the leaders of selected mRNAs. uORFs contained in these mRNAs are depicted by the thick horizontal lines.

References

    1. Alderete J P, Jarrahian S, Geballe A P. Translational effects of mutations and polymorphisms in a repressive upstream open reading frame of the human cytomegalovirus UL4 gene. J Virol. 1999;73:8330–8337. - PMC - PubMed
    1. Banks J D, Linial M L. Secondary structure analysis of a minimal avian leukosis-sarcoma virus packaging signal. J Virol. 2000;74:456–464. - PMC - PubMed
    1. Barak Y, Gottlieb E, Juvengershon T, Oren M. Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev. 1994;8:1739–1749. - PubMed
    1. Brown C Y, Mize G J, Pineda M, George D L, Morris D R. Role of two upstream open reading frames in the translational control of oncogene mdm2. Oncogene. 1999;18:5631–5637. - PubMed
    1. Calkhoven C F, Bouwman P R J, Snippe L, Ab G. Translation start site multiplicity of the CCAAT enhancer binding protein alpha mRNA is dictated by a small 5′ open reading frame. Nucleic Acids Res. 1994;22:5540–5547. - PMC - PubMed

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