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Review
. 2000 Nov 13;151(4):F15-8.
doi: 10.1083/jcb.151.4.f15.

The ups and downs of life in an epithelium

H Krämer  1
Affiliations
Review

The ups and downs of life in an epithelium

H Krämer. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
Proteins that compose different junctional complexes in Drosophila and vertebrate cells are conserved and localize to equivalent membrane domains. See text for further details.
Figure 2
Figure 2
Establishment of polarity is tightly coupled to cellularization in Drosophila embryos. The temporal order of membrane insertion is translated into spatial differences by the isolation of different membrane domains from the main site of insertion (Hunter and Wieschaus 2000; Lecuit and Wieschaus 2000). (A) Shortly after the initial stage of cellularization, (B) a first set of junctional complexes, marked by ARM, is formed just below the embryonic cell surface. These complexes seal off the most basal membrane domain that forms the furrow canals. (C) As cellularization proceeds, the initial set (red) of junctions move basally together with the furrow canals. A second set of junctions (blue) is formed just below the cell surface and separates the apical and lateral domains. Membrane insertion basal to these junctions continues to extend the lateral domain. (D) The furrow canals will form the basal membrane domains and shortly thereafter, as the embryo initiates gastrulation, the unusual basal junctions disappear.
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Comment on

References

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