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. 2000 Sep-Oct;96(5):564-6.

Helicobacter pylori serology and the diagnosis of H. pylori infection in children

Y Elitsur  1 , R Aflak, C Neace, W E Triest
Affiliations
  • PMID: 11077543

Helicobacter pylori serology and the diagnosis of H. pylori infection in children

Y Elitsur et al. W V Med J. 2000 Sep-Oct.

Abstract

Serological screening accuracy rate may be dependent on clinical and pathological determinants. The aim of this study was to evaluate the accuracy of Hp serology test (Roche Biomedical Lab., Labcorp), in the diagnosis of Hp infection in 121 children who were seen in the Pediatric Gastoenterology Clinic at the Marshall University Joan C. Edwards School of Medicine in Huntington. Positive serology detected children with Hp-associated gastritis with a sensitivity of 51.6%. Positive serology significantly correlated with the degree of gastric inflammation and density of Hp organisms in the gastric mucosa (ANOVA p < 0.001). The Labcorp. Hp-ELISA test had a poor accuracy rate for the detection of Hp-gastritis in children. Gastric biopsies should always be performed to establish the diagnosis of Hp infection in children.

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