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Case Reports
. 2000 Oct;45(10):823-6.

Uterine rupture and dehiscence associated with intravaginal misoprostol cervical ripening

D A Hill  1 , R A Chez, J Quinlan, A Fuentes, J LaCombe
Affiliations
  • PMID: 11077631
Case Reports

Uterine rupture and dehiscence associated with intravaginal misoprostol cervical ripening

D A Hill et al. J Reprod Med. 2000 Oct.

Abstract

Objective: To evaluate if the prostaglandin E1 analogue misoprostol, when used as an agent for cervical ripening, is associated with uterine rupture.

Study design: We performed a two-year retrospective chart review to determine the incidence of uterine rupture in patients with a previous cesarean delivery undergoing cervical ripening or the induction of labor.

Results: Uterine dehiscence occurred in 1 and uterine rupture occurred in 3 of 48 women with a prior cesarean delivery treated with 50 micrograms doses of intravaginal misoprostol for cervical ripening. Uterine rupture was found in 1 of 89 women who had an oxytocin infusion for induction of labor and none of the 24 patients who received intravaginal prostaglandin E2 placed for cervical ripening.

Conclusion: Intravaginal misoprostol appears to be associated with an increased incidence of uterine rupture when used in patients undergoing a trial of labor after cesarean.

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