Glomus tumors: report on eleven cases and a review of the literature

Abstract

Introduction: Glomus tumor is a well known pathology in hand surgery; in addition to sites in the upper limbs, it can also affect the lower limbs and develop in other parts of the body.

Materials and methods: Seven females and four males with glomus tumors underwent surgery between 1990 and 1998 at our hospital. These cases were retrospectively studied, and immunohistochemical staining was carried out for vimentin, factor VIII and CD34.

Results: At the time of diagnosis, the mean age of the patients was 49 years, with a mean follow-up of 18.5 months. Regarding tumor site, there were six digital, one wrist, two neck and two lower limb locations. In this series, familial incidence was observed in two cases, i.e., two sisters with tumor occurrence at the same digital site. Tumor size varied from 0.2 to 5 cm. In agreement with the findings in the literature, the present results showed only a low incidence of locations other than in the upper and lower limbs. Moreover, no multiple locations or degenerative malignancy were observed, both of which are known to be rare. In all cases, the histological aspect of these tumors was typically benign. Immunohistochemical studies of the tumor cells were positive for anti-vimentin antibody in all cases, negative for anti-factor VIII in all cases and irregularly positive for anti-CD34 antibody.

Discussion: It was not possible to confirm the specificity of the anti-CD34 antibody for glomus tumor in this series. The hypothesis of the endothelial origin of glomus tumor can probably be dismissed in the absence of the expression of anti-factor VIII and anti-CD34 antibodies.