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. 2000 Nov;79(11):941-6.

Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy. A retrospective study of 19 cases

N Berkane  1 , J J Cocheton, D Brehier, P Merviel, C Wolf, G Lefèvre, S Uzan
Affiliations
  • PMID: 11081677

Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy. A retrospective study of 19 cases

N Berkane et al. Acta Obstet Gynecol Scand. 2000 Nov.

Abstract

Objective: We studied the clinical and biological effects and safety of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy (ICP).

Methods: All cases of ICP treated with ursodeoxycholic acid in our department from January 1st, 1991 to May 31st, 1997 were reviewed.

Results: Forty-three patients had ICP, of whom 19 received ursodeoxycholic acid. The first symptoms appeared after a mean of 29.7 weeks of pregnancy (WP). Treatment was started after a mean of 32 WP, and lasted a mean of 28.5 days. Fourteen patients showed a clinical improvement on UDCA, and 11 showed a biological improvement. Two had a biological deterioration with increased liver enzyme concentrations.

Conclusions: Ursodeoxycholic acid appears to be an effective treatment for ICP, but further studies are needed to confirm its safety in pregnancy.

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