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. 2000 Oct;70(4):1168-71.
doi: 10.1016/s0003-4975(00)01529-0.

Prognostic factors in patients with surgically resected stages I and II non-small cell lung cancer

A R Jazieh  1 , M Hussain, J A Howington, H J Spencer, M Husain, J T Grismer, R C Read
Affiliations

Prognostic factors in patients with surgically resected stages I and II non-small cell lung cancer

A R Jazieh et al. Ann Thorac Surg. 2000 Oct.

Abstract

Background: About one-third to one-half of patients with early stages of non-small cell lung cancer (NSCLC) succumb to their disease. In this study, we attempted to identify prognostic factors that predict outcome in patients with stages I and II NSCLC.

Methods: A retrospective evaluation of 454 patients with surgically resected stages I and II NSCLC was performed to determine the impact of various clinical, laboratory, and pathological factors on patient outcome such as overall survival (OS) and event-free survival (EFS).

Results: Patients older than 65 years had shorter EFS and OS than younger patients (p = 0.002). Patients with preoperative hemoglobin less than or equal to 10 g% had shorter EFS and OS compared to patients with a hemoglobin greater than 10 g% (p = 0.001). Expectedly, OS and EFS were shorter in patients with stage II as compared to stage I patients (p < 0.001). In a multivariate analysis, age, hemoglobin level, and stage remain significant predictors for EFS and OS.

Conclusions: Older age, anemia, and higher stage are important prognostic factors in patients with surgically resected stage I and II NSCLC.

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