[Administration of natural anthocyanins derived from chokeberry retardation of idiopathic and preeclamptic origin. Influence on metabolism of plasma oxidized lipoproteins: the role of autoantibodies to oxidized low density lipoproteins]

Abstract

Purpose: To determinate the influence of anthocyanins from chokeberry on the generation of autoantibodies to oxidized low density lipoproteins (oLAB) in pregnancies complicated by intrauterine growth retardation (IUGR).

Material and methods: Study group consisted of 105 pregnant women (on the turn of II trimester according to LMP) with IUGR (sonographic examination results below 5th percentile for real gestational age) who were randomly divided into 2 groups: in 50 anthocyanins were administered, 55 women were on placebo; control group--60 healthy pregnant women. We examined the level of oxidative stress measured by serum concentration of autoantibodies to oxidized low density lipoproteins (oLAB).

Results: In the anthocyanin group oLAB titres decreased from 1104 +/- 41 mU/ml before treatment to 752 +/- 36 mU/ml (1st month) and 726 +/- 35 mU/ml (2nd month), p < 0.01. In the placebo group oLAB titres were of slightly increasing trend--1089 +/- 37 mU/ml before treatment, 1092 +/- 42 mU/ml (1st month) and 1115 +/- 43 mU/ml (2nd month), p > 0.05; oLAB tires in the control group: 601 +/- 49 mU/ml before treatment, 606 +/- 45 mU/ml (1st month) and 614 +/- 43 mU/ml (2nd month), p > 0.05.

Conclusions: Our results indicate that natural antioxidants (anthocyanins) can be useful in controlling of oxidative stress during pregnancies complicated by IUGR.