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Review
. 2000 Dec;84(6):587-94.
doi: 10.1136/heart.84.6.587.

Hibernating myocardium

R Schulz  1 , G Heusch
Affiliations
Review

Hibernating myocardium

R Schulz et al. Heart. 2000 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Sequential biopsy based measurements of the free energy change of ATP hydrolysis. Empty circles are data from single animals; filled circles are mean values; error bars represent 1 SD. The free energy change of ATP hydrolysis is decreased within the first five minutes of ischaemia, but subsequently recovers towards control values when ischaemia is prolonged to 90 minutes. Reproduced from Martin C, et al. Cardiovasc Res 1998;39:318-26, with permission of the publisher.
Figure 2
Figure 2
Infusion of dobutamine during moderate ischaemia results in only a transient increase in regional function. After 85 minutes of dobutamine infusion, however, regional work is reduced below the initial ischaemic value. Inset: Myocardial β adrenoceptor density does not change from control to five minutes of ischaemia and also remains constant throughout the subsequent 85 minutes of ischaemia with the additional dobutamine infusion.
Figure 3
Figure 3
(A): Increasing doses of intracoronary calcium increase regional work stepwise, both during normoperfusion and at 85 minutes of ischaemia. With ischaemia, the dose-response relation is displaced downwards. (B) The relations between the fractional increments in regional work and added intracoronary calcium are not different during normoperfusion and ischaemia. Modified from Heusch G, et al. Circulation 1996; 93:1556-66, with permission of the publisher.
Figure 4
Figure 4
Expression of the calcium regulatory protein SERCA and phospholamban. The expression of SERCA and phospholamban is not altered during experimental short term hibernation and subsequent reperfusion. Data are means, error bars = SEM. LAD, left anterior descending coronary artery; LCX, left circumflex coronary artery. Reproduced from Lüss H, et al. Cardiovasc Res 1998;37:606-17 , with permission of the publisher.
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